A Proposal for a Graduate Certificate Program in Nanoscience at Duke University
Approved: February 10, 2004 by the Executive
Committee of the Graduate Faculty
Proposal
Document Web URL: http://www.cs.duke.edu/~reif/GPNANO/
Program
Courses and Faculty Database URL: http://www.cs.duke.edu/nano/
Contacts:
Chair of Executive Committee for Nanoscience:
John Reif <reif@cs.duke.edu> (phone:660-6568)
Director
of Graduate Studies in Nanosience:
Stephen Teitsworth
<teitso@phy.duke.edu> (phone:660-2560)
1. Background and Rationale
1.1 The Nanoscience-Challenge and the Emergence of the
Discipline of Nanoscience
Nanoscience is an important new area of research that explores
materials and novel phenomena that occur at the size scale ranging from 1 - 100
nanometer, a range that encompasses both the smallest artificial structures and
ubiquitous molecules of the natural world. New fundamental phenomena such as
the chemical synthesis of nanoparticles, novel electronic devices based on
single electron dynamics, the interaction of cells with nano-patterned
surfaces, and the unfolding of proteins define the intellectual driving force
of this field. At the same time, the technological driving force consists in
potential applications of nanodevices in both medicine and engineering; these
applications include novel devices and structures for computation, local drug
delivery, and ultradense computer memory.
The challenges presented by nanoscience cannot be answered solely
by techniques and methods derived from a single science or technology
discipline. Instead, it requires a combination of diverse, but inter-related
techniques spanning many disciplines that form the core of an emerging
discipline of Nanoscience. These include, but are not limited to, quantum
physics, synthetic chemistry, density-functional simulation methods, biological
and chemical self-assembly, semiconductor device processing methods, and a
whole array of microscopies. Potential applications at this scale may well
provide for unprecedented benefits, but will require an even more diverse set
of methodologies, especially for applications in medicine and electronics.
We expect that this Nanoscience-challenge in science and
technology will be a major impetus to change the very way universities organize
their educational infrastructure in the next decade. While conventional
departments of a university such as Duke will still provide educational
instruction within their traditional domains, the demands for interdisciplinary
research training at the graduate level will require new interdisciplinary
infrastructure.
1.2 Growth in Nanoscience and Nanotechnology Efforts and
Funding
The National Science and Technology Council's subcommittee on
Nanoscale Science, Engineering and Technology, has taken the national lead in
promoting studies and federal support in this area. Adapting a definition given
by NSET (February 2000), we take Nanoscience and Nanotechnology to be basic research
and technology developments, respectively, “at the atomic, molecular or macromolecular levels, in the
length scale of approximately 1 - 100 nanometer range, to provide a fundamental
understanding of phenomena and materials at the nanoscale and to create and use
structures, devices and systems that have novel properties and functions
because of their small and/or intermediate size.”
A number of studies have also indicated substantial growth in
industrial nanoscale technology, including imaging devices, novel materials and
devices, and medical applications of nanotechnology. This is expected to result in a sustained high
rate of growth in employment opportunities; however, the educational
opportunities in the field have not kept pace with the substantially increasing
demand for individuals with the multidisciplinary training required for
nanotechnology.
The recent federal funding requests by the President for nanoscale science, engineering and technology are known as the National Nanotechnology Initiative (NNI) (http://nano.gov/). The FY 2003 request was for about $710 million, a 17% increase over FY 2002. It is anticipated that federal funding for this area will sustain similar substantial growth for many years in the future. This has resulted in many new funding programs at agencies such as the DARPA BIOCOMP and Molectronics Programs, the NSF Nanoscale Science and Engineering program (www.nsf.gov/home/crssprgm/nano), and the NIH Bioengineering Nanotechology Initiative.
In response to this growth of funding and industrial
opportunities, a number of Universities have recently initiated Centers and
Institutes in Nanoscience such as UC Berkeley’s Laboratory for Nano-Engineering
(www.nano.me.berkeley.edu), Rice University’s Center for Nanoscale Science and Technology
(http://cnst.rice.edu), Cornell University’s Center for Nanobiotechnology
(www.nbtc.cornell.edu), UCLA’ s California NanoSystems Institute
(www.cnsi.ucla.edu), and the University of Washington’s Center for
Nanotechnology (www.nano.washington.edu) among many others (see
www.nanotechnologyinstitute.org/links.html). Furthermore, there has been a
rapid growth in Nanoscience courses offered at universities (see a list at
www.nano.gov/courses.htm).
A number of graduate programs in nanoscience have also been
established, for example a Professional Masters Program in Nanoscale Physics at
Rice University (www.profms.rice.edu), and a nanotechnology graduate program at
University of Washington (www.nano.washington.edu/education). A number of NSF
IGERT grants have been made to nanotechnology graduate programs, including
notably Robert Clark’s Biologically Inspired Materials and Material System
Training Grant in the MEMS Department at Duke University.
The Government has also recently established a number of federal
Centers and Laboratories in Nanotechnology. For example, NASA Ames Research
Center established a Center for Nanotechnology, (www.ipt.arc.nasa.gov) and the
Naval Research Laboratory established an Institute of Nanoscience,
(nanoscience.nrl.navy.mil).
A list of many Centers and Institutions in Nanoscience can be
found at www.nanotechnologyinstitute.org/links.html.
1.3 Benefits to Duke of Interdisciplinary Nanoscience Graduate
Education
The above listed developments indicate a substantial growth in Nanoscience
and Nanotechnology funding and research nationwide. How does this impact Duke
University?
The answer is in part that these new funding programs in
Nanoscience and Nanotechnology are expanding at the expense of other funding
programs in more traditional areas of research. Duke University can take
advantage of this growth in funding programs in Nanoscience and Nanotechnology,
to expand its research presence in these areas. The proposed graduate program
will allow Duke University’s educational infrastructure to more directly
address the Nanoscience-Challenge described above, so as to increase the
ability to do top-flight Nanoscience and Nanotechnology, and to better compete
for federal support in this area. In particular, the science and engineering faculty’s
ability to execute interdisciplinary Nanoscience and Nanotechnology research
projects will be substantially improved by the development of an
interdisciplinary graduate program to support these research endeavors; and our
ability to attract to Duke and train the next generation of Nanoscientists will
be dramatically enhanced by such a program. These are the central motivations
for the proposed Graduate Certificate Program in Nanoscience at Duke
University.
In addition, the
proposed program is structured to address the unique Duke circumstances and
strengths at Duke, such as in the Medical Sciences.
1.4 Ongoing Nanoscience Research Focus Groups Currently at Duke
University
Research
in nanoscience spans and intersects with the activities of many departments at
Duke. To give some sense of the coherence and coordination of ongoing
nanoscience research at Duke, we can identify the following four focus areas (though
other classifications are certainly possible):
Synthesis
of nanostructured materials - The ability to make a variety of interesting and high
quality nanostructures is a key component of any nanoscience program. Exciting
recent examples of such synthesis activity at Duke (listed with their home
departments) include: carbon nanotubes (CHEM), metallic nanoparticles (CHEM),
semiconductor quantum dots (ECE), self-assembled organic thin films (BME), and
DNA-based structures (CS, BIOCHEM).
Fundamental
properties of nanostructured materials - The understanding and measurement of the
basic physical properties of novel nanostructures forms a core component of
nanoscience, from analysis of what nanostructure one has fabricated to the new
electronic, optical, and chemical properties that may result. Examples of
ongoing fundamental nanoscience research at Duke include: electron transport in
carbon nanotubes and DNA lattices (CHEM, CS, PHY), theory and simulation of
spin dynamics in quantum dots (CHEM, PHY), optical properties of semiconductor
quantum dots (ECE, PHY), studies of friction at the nanoscale (MEMS), and
nanoscopic aspects of protein-folding (BIOCHEM).
Nanodevice
fabrication and applications - Nanostructured materials have great potential
in practical applications. These cover a wide range of possibilities, including
biomedical devices, and potential for future electronic and optical devices.
Current activities at Duke include: micro- and nano-mechanical structures (ECE,
MEMS), enhancement of optical devices using nanotextured surfaces (ECE, PHY),
nanostructures for improved drug delivery (BME, MEMS), single electron
transistors (CHEM, PHY), and nanoscale modeling for improved drug design
(BIOCHEM, CHEM).
Advanced
characterization of nanostructured materials and devices - High-quality
characterization of the structural properties of nanostructured materials and
devices using state-of-art methods is a critical component to a successful
nanoscience effort. At Duke, characterization is primarily carried out in the
Shared Materials Instrumentation Facility (SMIF). Capabilities include
transmission and scanning electron microscopies, x-ray diffraction, x-ray
photoemission spectroscopy, and atomic force microscopy. The Duke SMIF also
incorporates important nanoscale processing tools; these include
electron-beam lithography for writing nanoscale patterns, and apparatus for
depositing highly uniform thin films of metals, oxides, and organic materials.
2.
Overview of the Proposal
This document, then, proposes a new Graduate Certificate
Program in Nanoscience (CPN), whose mission is to educate students in Nanoscience disciplines and
applications.
This graduate program is designed to address the need for an interdisciplinary
graduate education at Duke in Nanoscience that extends beyond the traditional
disciplines and skills that are taught within any existing department. In this
program, graduate students will be educated and mentored in classes, labs and
research projects by faculty from many disciplines. The disciplines will span
the physical sciences, engineering, and basic biological-science disciplines
relevant to Nanoscience; the program will include faculty from departments
within Arts and Sciences, the Pratt School of Engineering, and the Medical
School.
A number of departments will be designated Participating
Nanoscience Departments, and will be responsible for providing a set of core courses in
Nanoscience. Although other departments will likely join this group, the
present set of participating departments includes:
-
Department of Biology (BIO), College of Arts and Sciences;
-
Department of Chemistry (CHEM), College of Arts and Sciences;
-
Department of Computer Science (CS), College of Arts and Sciences
-
Department of Physics (PHYSICS), College of Arts and Sciences;
-
Department of Biomedical Engineering (BME), Pratt School of Engineering;
-Department
of Electrical and Computer Engineering (ECE), Pratt School of Engineering;
-
Department of Mechanical Engineering and Material Science (MEMS), Pratt School
of - Engineering;
-
Department of Biochemistry(BIOCHEM), School of Medicine;
-
Department of Cell Biology (CELLBIO), School of Medicine.
The administrative structure of the Graduate Program in Nanoscience has been
designed to ensure a high degree of openness, input and joint administrative
control by the various Participating Departments, so the program’s directions
and resources will not be directed to any individual’s or department’s
particular agenda. Each Participating Department will have equal representation
in the Executive Committee for the Nanoscience Program, as well as in other key
Committees including an Admission Committee and a Graduate Advising Committee.
The Dean of the Graduate School will appoint both the Chair of the Executive
Committee for the Nanoscience Program and also the Director of Graduate Studies
(DGS) in Nanoscience.
There will be two Seminar Series in Nanoscience, one of which will
be a highly visible Duke Nanoscience Seminar Series with lectures by external
invited speakers. The Nanoscience
Graduate Seminar Series will be organized by the Duke Nanoscience graduate students and
will feature lectures by Duke graduate students and faculty.
The Certificate Program in Nanoscience (CPN) is designed to augment
graduate programs in already existing University departments. Students in the
Certificate Program in Nanoscience will be admitted into existing departments
or programs of Duke University, and receive their PhD degrees within those
degree-granting units (typically but not exclusively a Participating
Department). The graduate
student will also be granted a Certificate in
Nanoscience upon: 1) satisfying a set of course requirements, 2) completion of an
approved project in association with a research group in Nanoscience outside
the student's home research group (for example, a
rotational training in a Nanoscience laboratory), and 3) involvement in the
Seminar Series in Nanoscience.
The
student's research advisor or student's home department or program will
generally be responsible for the financial support during the
"rotation" outside the student's research group. In the future, it is
hoped that this "rotation" will be funded by a program-training
grant.
The benefits of the Certificate Program in Nanoscience to the University are
many-fold:
(i) it meets the challenge of devising educational infrastructure
for a new brand of student whose training needs to go beyond traditional
departmental boundaries;
(ii) it provides a natural mechanism for forging collaborative
endeavors between faculty and labs of various distinct departments and schools,
via shared supervision of graduate students; and
(iii) it provides a response to the recent rapid growth in federal
funding and employment opportunities in Nanoscience, Nanotechnology, and their
applications.
Funding for the Certificate Program in Nanoscience will be simultaneously
sought from the following sources:
(1) By external federal funding, which will typically be in the
form of graduate training grants. This is intended to be, within a short period
of time not exceeding three years, the primary source of funding for the proposed
Certificate Program in Nanoscience.
(2) By initial modest support for a three year duration jointly
from Arts and Science, the Engineering School, and the Medical School.
(3) By
industrial support, which is anticipated to be initially of modest scale but
may grow to provide substantial support.
(4) Possible subsequent
establishment of a Masters Program in Nanoscience whose tuition would provide
partial support for doctoral students in the Certificate Program in
Nanoscience.
3.
Structure and Administration of the Certificate
Program in Nanoscience
3.1
Nanoscience Participating Departments
The
following departments will be deemed Nanoscience Participating Departments due
to their relevance to key science and engineering aspects of nanoscience, and
to the participation of individual faculty members in the program (It is
understood that in some areas, the numbers of department students particularly
interested in Nanoscience may be small.):
College
of Arts and Sciences:
- Biology
-
Chemistry
-
Computer Science
-
Physics
Engineering
School:
-
Biomedical Engineering
-
Electrical Engineering and Computer Engineering
-
Mechanical Engineering and Material Science
School of
Medicine:
-
Biochemistry
- Cell
Biology
The
Nanoscience Executive Committee will periodically update the list of
Nanoscience Participating Departments as chairs or other faculty seek
affiliation with the program and as departmental research is directed towards
issues involving Nanoscience and Nanotechnology.
3.2
Core Faculty of the Nanoscience Program
The
following faculty members have agreed to serve as “core faculty” of the
Graduate Certificate Program—meaning, in effect, that they are willing to
shoulder a portion of the instructional duties in the program and to mentor
graduate students pursuing the certificate. These are also faculty who define a
major component of their own research efforts as directed towards the study of
Nanoscience and Nanotechnology.
College
of Arts and Sciences:
Department
of Chemistry (CHEM), College of Arts and Sciences
Stephen
Craig <stephen.craig@duke.edu>
Jie
Liu <j.liu@duke.edu>
John
Simon <john.simon@duke.edu> Chair
Weitao
Yang <weitao.yang@duke.edu>
Department
of Computer Science (CS), College of Arts and Sciences
Thom
LaBean <thl@cs.duke.edu>
Alvin
Lebeck <alvy@cs.duke.edu>
John
Reif <reif@cs.duke.edu>
Xaiobai
Sun xiaobai@cs.duke.edu
Department
of Mathematics (MATH)
Stephanos
Venakides <ven@math.duke.edu>
Department
of Physics (PHYSICS), College of Arts and Sciences
Harold
Baranger <baranger@phy.duke.edu>
Chair
Albert
Chang <yingshe@physics.purdue.edu>
Henry
Everitt <everitt@phy.duke.edu>
Gleb
Finkelstein <gleb@phy.duke.edu>
Konstantin
Matveev <matveev@phy.duke.edu>
Stephen Teitsworth <teitso@phy.duke.edu>
Denis
Ullmo <ullmo@phy.duke.edu>
School
of Engineering:
Department
of Biomedical Engineering(BME), Pratt School of Engineering
Ashutosh
Chilkoti <chilkoti@duke.edu>
George A.
Truskey <george.truskey@duke.edu> Chair
Department
of Electrical and Computer Engineering (ECS), Pratt School of Engineering
April
Brown <abrown@ee.duke.edu> Chair
Chris
Dwyer <dwyer@ece.duke.edu>
Richard
Fair <rfair@ee.duke.edu>
Jungsang
Kim <jungsang@ee.duke.edu>
Hisham
Massoud <massoud@ee.duke.edu>
Department
of Mechanical Engineering and Material Science (MEMS), Pratt School of
Engineering
Stefano
Curtarolo <Stefano@duke.edu>
Earl
H. Dowell <dowell@ee.duke.edu>
Anne
Lazarides <aal@me1.egr.duke.edu>
Piotr
Marszalek <pemar@duke.edu>
Mark
Walters <Mark.Walters@duke.edu>
Stefan
Zauscher <zauscher@duke.edu>
School
of Medicine:
Department
of Biochemistry(BIOCHEM), School of Medicine
Homme
Hellinga <hwh@biochem.duke.edu>
David C. Richardson <dcr@kinemage.biochem.duke.edu>
Jane S. Richardson <jsr@kinemage.biochem.duke.edu>
Department
of Cell Biology (CELLBIO), School of Medicine
Sharyn
Endow <endow001@mc.duke.edu>
Harold
Erickson <H.Erickson@cellbio.duke.edu>
Notation:
* =
Member of the Nanoscience Executive Committee
3.3 The Executive Committee of the Certificate Program in Nanoscience
The administrative structure of the Graduate Certificate Program in
Nanoscience has been designed to ensure a high degree of openness, input and
joint administrative control via input by the various Participating
Departments, so the program’s directions and resources will not be directed to
any individual’s or department’s particular agenda.
The
Nanoscience Executive Committee is responsible for developing the Graduate
Program in Nanoscience and for recruiting, where appropriate, additional
faculty to participate in the program. The Nanoscience Executive Committee
consists of members of the Graduate Faculty selected from each of the distinct Participating
Departments, in addition to the DGS of the program.
The
initial members of the Nanoscience Executive Committee will be:
(i) John
Reif, Department of Computer Science (CS), College of Arts and Sciences;
(ii)
Stephen Teitsworth (DGS), Department of Physics (PHYSICS), College of Arts and
Sciences
(iii)
Philip Benfey, Department of Biology (BIO), College of Arts and Sciences;
(iv)
Jie Liu, Department of Chemistry (CHEM), College of Arts and Sciences;
(v)
Albert Chang, Department of Physics (PHYSICS), College of Arts and Sciences
(vi)
Ashutosh Chilkoti, Department of Biomedical Engineering (BME), Pratt School of
Engineering;
(vii)
Richard Fair, Department of Electrical and Computer Engineering (ECS), Pratt
School of Engineering;
(viii)
Robert Clark, Department of Mechanical Engineering and Material Science (MEMS),
Pratt School of Engineering;
(ix) David C. Richardson, Department of Biochemistry
(BIOCHEM), School of Medicine; and
(x) Vann
Bennett, Department of Cell Biology (CELLBIO), School of Medicine.
The
Executive Committee will be responsible for advising on all aspects of the
operation of the program, including curriculum, admissions, student advising,
financial support and grant proposal development, and seminars. The Executive
Committee will operate primarily via standing committees: the Curriculum
Committee, the Nanosciences Certificate Admission Committee, the Seminar
Committee, and the First-year Advising Committee. The Executive Committee will
nominate the membership of these other committees. Replacements of these
members will be nominated by the Chairs of the individual participating
departments.
Chair
of the Nanoscience Executive Committee. The Chair of the Nanoscience Executive Committee will be
responsible for executive tasks associated with the Committee such as
scheduling, chairing, and reporting on the Committee’s meetings, as well as
external communications. The Chair of the Nanoscience Executive Committee will
also be responsible, jointly with the DGS, for grant proposal writing in
support of the program. The Chair of the Nanoscience Executive Committee will
be appointed by the Dean of the Graduate School.
Director
of Graduate Studies (DGS) in Nanoscience
The DGS
will be responsible for the day-to-day oversight of the certificate program,
including initial student advising and student recruitment. The DGS will also
serve as a member of the Executive Committee, the Curriculum Committee, and the
Nanoscience Certificate Admission Committee, with full voting rights within
these committees. The DGS certifies completion of the requirement for the
nanoscience certificate based on the recommendation of the student's individual
Advisory committee, and notifies the Graduate School so that the formal
certificate may be awarded. The DGS also appoints the individual advisory
committees for each student. The DGS will be responsible, jointly with the
Chair of the Nanoscience Executive Committee, for grant proposal writing in
support of the program. The DGS in Nanoscience will
be appointed by the Nanoscience Executive Committee. The Nanoscience Steering Committee has unanimously
nominated that Stephen Teitsworth, of the Physics Department, to be the initial
DGS in Nanoscience.
Nanoscience
Certificate Admission Committee
The
Nanoscience Admission Committee will consist of at least three members of the
Nanoscience Graduate Faculty selected from distinct Participating Departments.
It will be responsible for admitting graduate students into the Nanoscience
Graduate Program.
The
Curriculum Committee will consist of at least three members of the Nanoscience
Graduate Faculty selected from Participating Departments. It will be
responsible for selection and development of the Curriculum, including
Nanoscience Core Courses and suggested Elective courses.
Seminar
Committee
The
Seminar Committee will consist of at least three members of the Nanoscience
Graduate Faculty selected from Participating Departments. It will be
responsible for selection of weekly Nanoscience Seminar speakers. The initial
Chairs of the Seminar Committee will be Anne Lazarides and Thomas LaBean.
Nanoscience
Advisory Committees: A
distinct Nanoscience Advisory Committee will be appointed for each student in
the certificate program. Each Advisory Committee will be composed of at least
three Nanoscience graduate faculty members, with at least one in the student’s
home department and at least one in a different Participating Nanoscience
Department. Each Advisory committee will be appointed and approved by the DGS.
This committee: 1) approves the nanoscience-related courses to be taken by the
student, 2) approves the student's proposal for a substantive project outside
the student's home research group as well as the duration of that project, 3)
examines and grades the final written and/or oral report that results from the
project, and 4) makes the final recommendation to award the Nanoscience
graduate certificate to the DGS.
4. Details of the Proposed Graduate Certificate in
Nanoscience
4.1
Admission
In
the proposed Certificate Program in Nanoscience, PhD graduate students are to
be admitted to an existing (home) academic department. That home department
will award the student a PhD upon completion of the home departmental
requirements. In addition, the student will also be awarded a Certificate in
Nanoscience after completion of the requirements described below.
The
admission of a graduate student into the Certificate Program in Nanoscience
will be simultaneous with, or subsequent to, the admission of the graduate
student into an existing University department. A graduate admissions committee
comprised of as least one member from each of the core participating
departments will formally admit students into the Certificate Program in
Nanoscience.
4.2
Requirements
The
Graduate Curriculum for a Certificate in Nanoscience:
To
be awarded a Certificate in Nanoscience, a student must:
(1)
be enrolled in the Certificate Program in Nanoscience for at least two years; have
a Nanoscience Advisory Committee appointed and approved by the Nanoscience DGS;
complete the requirements for a PhD in their department, with a PhD thesis
committee containing at least one member of thecore Nanoscience faculty;
(2)
take the following required courses:
(a)
take the single semester course NANO200 Foundations of Nanoscience,
(b)
take the single semester course NANO201 Nanoscience Laboratory+,
(c)
take the single semester course NANO202 Nanoscience Graduate Seminar and attend
the Nanoscience Graduate Seminar throughout the period of the student’s
enrollment in the Certificate Program in Nanoscience;
(d)
take a one semester elective course or three one month short courses chosen
from an approved list of Nanoscience courses at Duke University, and
(3)
complete a pre-approved project of duration approximately one to two months
(the project and its duration must be pre-approved by the student’s Advisory
Committee) in association with a research group in Nanoscience outside the
student's dissertation group, to be described by a written report or poster
presentation (for example, an experimental student in physics may take a
rotation in another laboratory at Duke University, while a theoretical student
in physics may do a project in a software laboratory). As mentioned in Section
2, the student's the research advisor or student's department would generally
be responsible for the financial support during a "rotation" outside
the student's research group.
+Note: For students pursuing numerical or
theoretical research as their primary focus, the required Nanoscience
Laboratory course NANO201 may be replaced by one additional full term course
that is either:
(a)
a
computational methods course (Math224, Math225, Math226, Math 229, CS230 or
CS250 or equivalent), or
(b)
a course in
the area of molecular or computational biology software techniques and tools
(for example CPS260 Algorithms in Computational Biology, or BCH222 Structure of
Biological Macromolecules), or,
(c)
an elective course on the approved list
of Nanoscience courses at Duke or a course approved by the Nanscience DGS, with
the requirement that the course not be in the student's home department.
4.3
Required Courses in Nanoscience
NANO200:
Foundations of Nanoscience
Instructor:
Chris Dwyer <dwyer@ece.duke.edu> (660-5275) primary instructor. Also, Thomas
LaBean, Jie Liu, John Reif, Stephen Teitsworth, and Mark Walters will give
lectures in sections.
Description:
This is a one-semester 200 level graduate course designed to introduce
nanoscience as a new discipline by integrating important components of the
broad research field together. It's integrated approach to nanoscience and
nanotechnology, will cross the traditional disciplines of biology, chemistry,
computer science, engineering, and physics. It will expose graduate students to
fundamental aspects of nanoscience without requiring graduate level
prerequisites. Since the discipline of nanoscience is enabled by tools such as
the atomic force microscope (AFM), SEM, TEM, etc., these tools will be
presented as a central aspect of the course. Also, software tools for the
design and modeling of nanostructures will be introduced. Other topics will
include synthesis, assembly and properties of nanomaterials.
Syllabus:
The course will begin with a one-week overview on the broad aspects of nanoscience
(John Reif, Dept of CS). The remaining course is divided into four sections,
each of 3 weeks:
1)
Tools (Mark Walters, Shared Materials Instrumentation Facility, Dept of MEMS) -
focuses on a key set of instruments (e.g., atomic force microscopy and electron
microscopy) that have enabled the creation, measurement, and control of
nanostructures.
2)
Synthesis (Jie Liu, Dept of Chemistry & other faculty) - covers key
principles and methods of chemistry and materials science that allow the
creation of a variety of nanostructures (e.g., Carbon nanotubes and quantum
dots).
3)
Assembly (Thomas LaBean, Dept of CS & other faculty) - provides a
description of both the traditional top-down methods for assembly, such as via
ebeam lithography, as well as self-assembly techniques for constructing
nanostructures.
4)
Properties (Stephen Teitsworth, Dept of Physics & other faculty) - provides
a description of key novel mechanical, electronic and optical phenomena that
can be achieved in nanostructures.
NANO201:
Nanoscience Laboratory
Instructors:
Mark Walters, Dept of MEMS & other staff of Shared Materials
Instrumentation Facility
Description: This is a one-semester 200
level graduate course designed to introduce basic tools used in nanoscience for
characterization, imaging and fabrication of nanostructures. The discipline of
nanoscience is enabled by characterization and imaging tools such as the atomic
force microscopy (AFM), electron microscopy (SEM, TEM), and X-ray techniques
(X-Ray diffraction and XPS). These tools will be presented as a central aspect
of the course. In addition, cleanroom processing methods that enable the
fabrication and characterization of nanostructures will be presented.
Syllabus: The course will focus on giving
a hands-on introduction to characterization and clean room based processing
methods that play an important role in the fabrication and characterization of
nanostructured materials. Clean-room based processing methods to be covered
include: basic photolithography, evaporation, electron beam lithography, and
wet and dry etching. Characterization methods to be covered include: atomic
force microscopy, scanning electron microscopy, transmission electron
microscopy, X-ray diffraction, and X-Ray photoelectron spectroscopy.
Notes:
(1)
The NANO201: Nanoscience Laboratory Course is not intended to constitute the
pre-approved project listed in part 6 of the Requirements for Graduate
Certificate in Nanoscience.
(2)
It has been estimated that this lab fee would be around $1200 per student for
the entire semester course.
NANO202:
Nanoscience Graduate Seminar
Instructors:
TBA
Description:
The course is designed to provide graduate students with in depth coverage of
research topics in Nanoscience. Students will be required to attend both the
External and Internal Lecture Series in Nanoscience. The class will also meet
to discuss papers in the topical research areas covered by the Lectures Series
in Nanoscience.
Syllabus:
The
Lecture Series in Nanoscience that students will be required to attend are:
(a)
A monthly External Lecture Series in Nanoscience, to be jointly run by Anne
Lazarides and Thomas LaBean, with monthly speakers invited from other
institutes, and to include one distinguished lecture per semester.
(b)
An Internal Seminar Series in Nanoscience, meeting every two weeks. The
meetings will cover basic research topics Nanoscience area. Each Internal
Seminar Series meeting will concentrate on a given area of Nanoscience and will
run a total of 1 hour. Each meeting will consist of three segments given by
distinct Duke speakers of a given department: a 20 min. introductory overview
and two further 20 min. short talks on distinct subtopics in the area.
The
class also will meet prior to the lectures to discuss papers in topics covered
by these lectures; these papers will include both overview survey papers as
well as technical publications in these topics.
3.4
Elective courses in Nanoscience:
Note:
All listed provide
instruction in basic science areas that impact Nanoscience. The * indicates
core electives where nanoscience content has already been introduced to the
course. The + indicates core electives where there is an opportunity for
appropriate nanoscience content to be introduced to the course in the future.
Chem
321: Inorganic Chemistry (Dept of Chemistry)
Instructors:
TBA
Description:
Bonding and spectroscopy, reactions, transition metal chemistry, main group
chemistry, organometallics/catalysis, and solid state.
Chem
304: Separation Science (Dept of Chemistry)
Instructors:
TBA
Description:
Fundamental separation chemistry, practical aspects of chromatographic methods,
larger scale processes. Prerequisite: Analytical Chemistry 301 or permission of
instructor.
+
CHEM 326: Transition Metal Ion Reactivity and Mechanisms (Dept of Chemistry)
Instructors:
Crumbliss
Description:
A discussion of the mechanism of reactions of coordination compounds and
transition metal organometallics in solution. Examples include ligand
substitution, isomerisation and redox reactions, catalysis, and linear free energy
relationships.
http://www.chem.duke.edu/graduate/courses.html
CHEM
331: Organic Chemistry (Dept of Chemistry)
Instructors:
TBA
Description:
Bonding and structure, stereochemistry, conformational analysis, substitution,
addition, and elimination reactions, carbon reactive intermediates, concerted
reactions, photochemistry. carbon alkylation, carbonyl addition, nucleophilic
substitution, electrophilic additions, reduction, cycloadditions,
rearrangements, main group organometallics, oxidation.
http://www.chem.duke.edu/graduate/courses.html
CHEM
334: Physical Organic Chemistry (Dept of Chemistry)
Instructors:
Craig
Description:
A graduate course overview of intermolecular interactions in organic,
supramolecular, and materials chemistry.
This course covers intermolecular interactions including hydrogen
bonding, multipole electrostatic interactions, solvophobicity, and size and
shape complementarity. Emphasis is then given to the rational design of
self-assembling, supramolecular structures and the properties of the assembled
materials. The course concludes with a discussion of templated recognition
(catalytic antibodies, imprinted polymers, and dynamic combinatorial
libraries), particularly in biology and biological materials. Prerequiste:
Organic Chemistry 331.
http://www.chem.duke.edu/graduate/courses.html
Chem
328: Synthesis and Synthetic Methods in Inorganic/Organometallic Chemistry
(Dept of Chemistry)
Instructors:
TBA
Description:
A discussion of inorganic synthetic methods including supramolecular chemistry
and organometallic reactions.
*
PHY346: Introduction to electronic nanophysics
(Dept of Physics)
Instructors:
Denis Ullmo
Description: The
aim of this course is to provide the theoretical background necessary to
understand the electronic properties specific to nanostructures. Although this
will be a theory course, the main emphasis will not be on theoretical techniques. Rather, the focus is on the
conceptual differences introduced when considering "nanoscale"
objects, and the introduction of necessary theoretical. As such, this course
should be useful for students interested in (or considering the possibility of)
doing their Ph.D. work in experimental as well as theoretical nanophysics.
Prerequisites:
PHY 307 or permission of the instructor.
PHY 246S (crosslisted with Biology 295S) (Dept of
Physics)
Title:
Physical Approaches to the Living Cell
Instructors:
Glenn Edwards (PHYSICS) and Dan Kiehart (BIOLOGY)
Description:
A seminar course for advanced undergraduates and graduate students investigating
the biophysics of the cell, development, morphogenesis, and wound healing.
Syllabus:
Topics will be drawn from: light as a tool for biology, modern microscopy,
fluorescence with green fluorescence protein; low-Reynolds number dynamics of
morphogenesis; cytokinesis; leaf morphogenesis; reaction rates in one, two, and
three dimensions; and diffusion, gradients, morphogens, and pattern formation.
Prerequisite:
consent of instructor.
+
PHY 307: Introduction to Condensed Matter Physics
(Dept
of Physics)
Instructor:
Finkelstein or Teitsworth
Description:
This course is a graduate level introduction to condensed matter physics. The
course requires some familiarity with quantum mechanics and statistical
mechanics.
Syllabus:
Microscopic structure of solids, liquids, liquid crystals, polymers, and spin
structures; elastic scattering and long-range order; topological defects;
electronic structure of crystals (metals and semiconductors); phonons and
inelastics scattering; magnetism; superconductivity.
PHY310:
Advanced Solid State Physics (Dept of Physics)
Instructor:
Matveev
Description:
This is a graduate level introduction to solid state physics.
Syllabus:
Advanced energy band theory; Fermi liquid theory; many-body Green functions and
diagrammatic techniques; interacting electron gas; superconductivity;
magnetism; applications.
Prerequisites:
PHY 307, or equivalent, or permission of the instructor.
CHEM
348: Solid State Chemistry (Dept of Chemistry)
Instructor:
Liu
Description:
Introduction to the structure, physical and electronic properties of
solid-state materials.
+
CHEM 311: Biological Chemistry (Dept of Chemistry)
Instructors:
Grinstaff
Description:
Chemistry of the major classes of biological molecules, including nucleic
acids, amino acids and proteins, carbohydrates and lipids. Topics to be covered
include structure, reactivity and synthesis, and the interaction of biological
molecules.
http://www.chem.duke.edu/graduate/courses.html
+
CHEM 336: Bioorganic Chemistry (Dept of Chemistry)
Instructors:
Grinstaff
Description:
Basic enzymology, mechanisms of enzymatic reactions, cofactors,
oxidoreductases, C1 chemistry, carbon-carbon bond formation,
carboxylation/decarboxylation, heme, pyridoxal enzymes, thiamine enzymes.
Prerequisite: Biological Chemistry 311 or equivalent.
http://www.chem.duke.edu/graduate/courses.html
+
CB2XX: Physics of Biological Polymers in Aqueous Environments (Dept of Cell
Biology)
Instructors:
TBA
Description:
This short course would cover physical properties of proteins (including molecular
motors), nucleic acids, and complex carbohydrates in aqueous solution.
Course
text book: J. Howard Mechanics of motor proteins and the cytoskeleton Sinauer
Associates, Inc, Sunderland, Massachusetts (2001).
CB251:
Molecular Cell Biology (Dept of Cell Biology)
Instructors:
Erickson & Cell Biology faculty
Description:
This an advanced course covering topics in cell biology with an emphasis on
reading primary literature and identifying new research questions. Requires
undergraduate background in cell biology.
Syllabus:
CBI 251 covers a broad range of topics in modern cell biology, with an emphasis
on reading primary research papers.
Areas covered include membrane
organelles and protein trafficking; cytoskeleton and cell motility; cell cycle
and cell signaling mechanisms; developmental biology; molecular based diseases.
+
BME220L: Introduction to Biomedical Engineering (Dept of Biomedical
Engineering)
Instructors:
Chilkoti, Carlson
Description:
BME 220L provides an introduction to the basic building blocks of
bimolecules--amino acids, nucleotides, sugars and lipids, and their
organization into higher order structures such as proteins and DNA. Students
are introduced to the principles and techniques of molecular biology, which are
directly applied in laboratory modules that begin with purification and
characterization of plasmid DNA, and culminate in the expression and
purification of an artificial elastin-like polypeptide in the laboratory
component.
http://bme-www.egr.duke.edu/gradprog_curriculum.php#gradconcentration
BME
207: Transport Phenomena in Biological Systems
(Dept
of Biomedical Engineering)
Instructor:
Yuan
Description:
Elements of fluid mechanics, introduction to diffusion concepts, and
applications of differential transport equations.
BME
247: Drug Delivery (Dept of Biomedical Engineering)
Instructors:
Yuan
*
CPS296.5: Molecular Computing (Dept of Computer Science)
Instructors:
Thomas H. LaBean
Description:
We will cover DNA computing, molecular electronics, and related fields with a
focus on the design, fabrication, use, and development of computing systems
with molecular-scale components. Previous knowledge of chemistry or
macromolecular structure is not required. The course is appropriate for
graduate students and advanced undergrads in engineering, computer science,
materials science, chemistry, and biomedical fields.
Syllabus:
Introduction
to Biopolymer Structure (Nucleic acid and protein models, MAGE)
Methods:
Molecular biology, chemistry, microscopy (AFM, TEM, SEM, STM, etc.)
DNA-Based
Computing. Principles and Historic Development
DNA-Based
Nanofabrication. Self-Assembling DNA Tilings as Structural Templates
Molecular
Electronics
BioChips
-- Surface Based Chemistry (DNA and Protein Chips)
*
ECE2xx: Nanoelectronics (Dept of Electrical and Computer Engineering)
Instructors:
April Brown, Richard Fair, and Hisham Massoud
Description:
The course will cover materials and devices for nano-scale electronic circuits.
*
CPS 222: Nanocomputers (Dept of Computer Science)
Instructors:
Lebeck
Description:
Design and analysis of nano-scale computing devices. Topics include
nanoelectronic devices (e.g., carbon nanotube transistors, quantum cellular
automata, etc.), computational paradigms, component design, defect and fault
tolerance, fabrication techniques (e.g., self-assemblies), modeling and
simulation methods.
*
CPS296.x : Biomolecular Nanotechnology (Dept of Computer Science)
Instructors:
Thom LaBean
Description:
This course will cover the use of biological macromolecules (especially proteins
and nucleic acids) for self-assembly and templating of nanostructured
materials.
*
CPS296.x: Design of DNA nanostructures (Dept of Computer Science)
Instructors:
Thomas LaBean and Hao Yan
Description:
This is a short, 4 week course covering topics required for the design of DNA
nanostructures.
Syllabus:Topics
include basic DNA motifs including DX, TX and 4 x 4 Tiles, and periodic DNA
lattices. Also, methods for the disign of DNA motifs and use of software for
the design of sets of DNA tiles.
*
CPS296.x: Molecular Robotics (Dept of Computer Science)
Instructors:
John Reif and Hao Yan
Description:
The course will provide a basic graduate level introduction to various topics
in the design and self-assembly of molecular robotic devices and affectors,
including protein motors and DNA robotics.
MEMS2xx:
Mechanics of Motor Proteins
(Dept of Mechanical
Engineering and Material Science)
*
MEMS2xx: Nano Surface Characterization (Dept of Mechanical Engineering and
Material Science)
Instructor:
Piotr Marszalek
Description:
Introduction to surface probe techniques (e.g. Scanning Tunneling Microscopy,
Atomic Force Microscopy) and other methodologies to manipulate and observe
nanoscale systems (single molecule force spectroscopy, optical trapping, single
molecule fluorescence microscopy). Mechanical properties of single molecules
and inorganic clusters of atoms (nanowires) adsorbed to surfaces. Introduction
to modeling at the nanoscale. Special emphasis will be given to nanoscale
systems in biology and how these systems inspire nanotechnology.
MEMS208:
Introduction to Colloid and Surface Science
(Dept
of Mechanical Engineering and Material Science)
Instructors:
Needham, Zauscher
+
MEMS 209: Soft Wet Materials and Interfaces
(Dept
of Mechanical Engineering and Material Science)
Instructors:
Needham
Description:
The materials science and engineering of soft wet materials and interfaces.
Emphasis on the relationships between composition, structure, properties and
performance of macromolecules, self assembling colloidal systems, linear
polymers and hydrogels in aqueous and nonaqueous liquid media, including the
role of water as an ''organizing'' solvent. Applications of these materials in
biotechnology, medical technology, microelectronic technology, and nature's own
designs of biological materials.
+
MEMS211: Theoretical and Applied Polymer Science
(Dept
of Mechanical Engineering and Material Science)
Instructors:
Zauscher
Description:
This is an advanced course in polymer materials science dealing specifically
with the relationship between structure and properties of macromolecules.
Applications in biology and medical technology are discussed.
*
MEMS265.2: Interaction of radiation with
nanostructured matter. (Dept of Mechanical Engineering and Material
Science)
Instructors:
Anne A. Lazarides
Description: Optical properties of nanoparticles, nanoparticle
materials, surfaces,interfaces, and nanoparticles on substrates. Use of
radiation as a probe of nanostructure. Particle plasmons, surface plasmons, and
coupling between them. Substrate and cavity modulation of lifetimes and
resonant frequencies of particles and of fluorescent molecules. Soft matter
modulation of the optical properties of nanostructured matter. Applications to
molecular detection, and to nanostructured light-emitting and waveguiding
devices.
Prereqs:
undergrad physics, chemistry, differential equations, and,
preferably, a course in electricity and magnetism.
*
MEMS310: Nanomechanics: From Molecules to Materials (Dept of Mechanical
Engineering and Material Science)
Instructors:
Clark, Craig, Erickson, Zauscher
Description:
This is a new, interdisciplinary course that provides exposure to inter- and
intramolecular force measurements, nanomechanics and scanning probe microscopy.
The course begins with a review of thermodynamic equilibria and dynamics,
discusses molecular mechanics of bond stretching, bending and torsion. Entropy
and intramolecular forces in macromolecules will receive special attention. A
significant portion of the course is dedicated to a discussion of force
spectroscopy, ranging from the elastic behavior of single macromolecules,
interactions of polymer-decorated surfaces, to adhesion and contact mechanics.
The course will provide an introduction to the mechanics of extracellular
matrix proteins, structural bipolymers, and "smart gels." A
laboratory component, which involves the use of AFMs and single-axis force
spectrometers, will reinforce classroom concepts through hands-on experience.
+
BCH222: Structure of Biological Macromolecules (Dept of Biochemistry)
Instructors:
Jane and David Richardson
Description:
This is a seminar/lab course in the 3D structure of macromolecules, primarily
using computer graphics. working with kinemages and the Mage display programs.
Also demonstration of brass or plastic molecular models for Crystallographic
Model Building. Topics include: H-bonds & Helices, alpha / beta Proteins,
The Ribosome, All-atom Contacts Analysis.
+
CPS260: Algorithms in Computational Biology
(Dept of Computer Science)
Instructors:
Pankaj Agarwal alternating with Alexander Hartemink
Description:
This course is intended to provide a systematic introduction to the algorithms
behind the most commonly-used tools in computational biology. While the course
will survey a wide range of methods in the field and provide a significant
amount of exposure to actual tools, its primary emphasis will be on
understanding and analyzing the algorithms behind these tools. In the process,
students will be introduced to common techniques in algorithmic design and
analysis, including design of data structures and analysis of running time.
Syllabus:
Topics covered include dynamic programming, string matching, probabilistic
techniques, geometric algorithms, hidden Markov models, data mining, and
complexity analysis. These topics will be explored in the context of
applications of genome sequence assembly, protein and DNA homology detection,
gene and promoter finding, protein structure prediction, motif identification,
analysis of gene expression data, functional genomics, phylogenetic trees, and
evolutionary sequence comparison, time permitting.
Assignments
will be primarily in the form of problem sets with a mix of algorithm analysis
and application. Students will also be given the option of completing a group
research project in place of a number of the problem sets.
Students
are expected have previous exposure to probability theory and statistics, as
well as a familiarity with basic concepts of cell biology. All necessary
background will be provided as a review, but at a relatively brisk pace.
Students are certainly encouraged to speak with the instructor if they are
interested in the course but are concerned about prerequisites.
http://www.cs.duke.edu/education/courses/fall02/cps296.5/
5.
Appendix
Faculty
Affiliated with the Nanoscience Graduate Program
Notation:
# =
Core Faculty of the Nanoscience Program
* =
Member of the Nanoscience Executive Committee
Any
required replacement member of the Nanoscience Steering Committee is to be
designated by the Chairman of the corresponding Department.
College
of Arts and Sciences:
Department
of Biology (BIO), College of Arts and Sciences
*Philip
Benfey <Philip.Benfey@duke.edu> Chair
(phone: 613-8182 cell 917-754-5071)
Dan
Kiehart <dkiehart@duke.edu>
Sonke
Johnson <sjohnsen@duke.edu>
Department
of Chemistry (CHEM), College of Arts and Sciences
Boris
Akhremitchev <boris.a@duke.edu>
David
Beratan <david.beratan@duke.edu>
Alvin
L Crumbliss <alvin.crumbliss@duke.edu>
#*Jie
Liu <j.liu@duke.edu> 660-1549
#Weitao
Yang <weitao.yang@duke.edu>
#Stephen
Craig <stephen.craig@duke.edu>
#John
Simon <john.simon@duke.edu> Chair
Department
of Computer Science (CS), College of Arts and Sciences
Herbert
Edelsbrunner <edels@cs.duke.edu>
Alexander
Hartemink <amink@cs.duke.edu>
#Thom
LaBean <thl@cs.duke.edu>
#Alvin
Lebeck <alvy@cs.duke.edu>
#*John
Reif <reif@cs.duke.edu> (phone:660-6568)
Xaiobai
Sun <xiaobai@cs.duke.edu>
Department
of Physics (PHYSICS), College of Arts and Sciences
#Harold
Baranger <baranger@phy.duke.edu>
#*Albert
Chang <yingshe@physics.purdue.edu> (fall,2003)
Glenn
Edwards <edwards@fel.duke.edu>
#Henry
Everitt <everitt@phy.duke.edu>
#Gleb
Finkelstein <gleb@phy.duke.edu>
Dan
Gauthier <gauthier@phy.duke.edu>
#Konstantin
Matveev <matveev@phy.duke.edu>
#*Stephen
Teitsworth <teitso@phy.duke.edu> (phone:660-2560)
Shailesh
Chandrasekharan <sch@phy.duke.edu>
#Denis
Ullmo <ullmo@phy.duke.edu>
School
of Engineering:
Department
of Biomedical Engineering(BME), Pratt School of Engineering
#*Ashutosh
Chilkoti <chilkoti@duke.edu> (phone660-5373)
Monte
Reichert <reichert@duke.edu>
#George
A. Truskey <george.truskey@duke.edu> (chair)
Department
of Electrical and Computer Engineering (ECS), Pratt School of Engineering
David
Brady <latshaw@ee.duke.edu>
#April
Brown <abrown@ee.duke.edu>
#Chris
Dwyer <dwyer@ece.duke.edu> (660-5275)
#*Richard
Fair <rfair@ee.duke.edu> (phone:660-5277)
Jungsang
Kim <jungsang@ee.duke.edu>
#Hisham
Massoud <massoud@ee.duke.edu>
Dan Sorin
<sorin@ee.duke.edu>
Department
of Mechanical Engineering and Material Science (MEMS), Pratt School of
Engineering
*Robert
Clark <rclark@duke.edu> (phone:660-5435)
#Stefano
Curtarolo <Stefano@duke.edu>
#Earl
H. Dowell <dowell@ee.duke.edu>
#Anne
Lazarides <aal@me1.egr.duke.edu> 660-5483
David
Needham <david.needham@duke.edu>
Piotr
Marszalek <pemar@duke.edu>
#Mark
Walters <Mark.Walters@duke.edu> 919-660-5486
#Stefan
Zauscher <zauscher@duke.edu>
School
of Medicine:
Department
of Biochemistry(BIOCHEM), School of Medicine
#Homme
Hellinga <hwh@biochem.duke.edu> (phone:681-5885)
Christian
R.H. Raetz <raetz@biochem.duke.edu> (919) 684-5326 Chair
#*David C. Richardson <dcr@kinemage.biochem.duke.edu>
#Jane S. Richardson <jsr@kinemage.biochem.duke.edu>
Department
of Cell Biology (CELLBIO), School of Medicine
*Vann
Bennett <benne012@mc.duke.edu> (phone: 919-684-3538, 919-684-3105) (also
Department of Biochemistry)
#Sharyn
Endow <endow001@mc.duke.edu>
#Harold
Erickson <H.Erickson@cellbio.duke.edu>
Mike
Reedy <mike.reedy@cellbio.duke.edu>
Thomas J.
McIntosh <t.mcintosh@cellbio.duke.edu>
Other
Departments with Faculty Research Interests in Nanoscience:
Department
of Mathematics (MATH)
#Stephanos
Venakides <ven@math.duke.edu> (phone 660-2815)
Department
of Pathology (PATH)
Dan Kenan
<kenan001@mc.duke.edu> (phone: 681-5754 or pager 970-1468)
Duke
Administration with Interests in Nanoscience Graduate Programs:
+James
Siedow <jim.siedow@duke.edu> Vice Provost for Research (phone:
681-6438)(lab 613-8181)
+Lewis M.
Siegel <lmsiegel@duke.edu> Dean of the Graduate School (phone: 681-3257)
Leigh
Deneef <leigh.deneef@duke.edu>Associate Dean of the Graduate School
John
Harer <John.Harer@duke.edu> Vice Provost for Academic Affairs
Kristina
Johnson <kristina.johnson@duke.edu>, Dean of the School of Engineering
Berndt
Mueller <muller@phy.duke.edu> Dean of Natural Sciences