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Here is a sample page from my R01, so you can see what these LaTeX files produce.
Quick start: Download from CTAN, nih.zip, nih.tgz, or my source files. I usually use nih.cls these days (in the zip file), which I have now updated to conform to "PHS 398/2590 Rev 09/04."
Here is the "blank" version for use with electronic submissions to NIH.
If you make improvements or enhancements (e.g., to the .sty or
.tex files) I would be grateful if you could send me a copy, to
this Email.