OSPREY
RDC-PANDA
DISCO
NASCA
POOL
Q5
CRANS
Software previously released by the Donald Lab:
Exact-2NH
MTC
NVR/HD/GD
Rage/Enrage
Software Developed by the Donald Lab
DISCO
Download DISCO v1.0 | Download Source | License | Contact
Welcome to the website for the DISCO software. Here, you can download the newest version of DISCO, the source code of DISCO, read the license agreement, and e-mail us inquiries.
Instructions for installing and using DISCO, as well as citation instructions and the licensing agreement can be found in the README file included in the distribution.
About DISCO
DISCO is software to perform structure determination of protein homo-oligomers with cyclic symmetry, and was developed in the lab of Prof. Bruce Donald at Duke University. DISCO computes oligomeric protein structures using geometric constraints derived from RDCs and intermolecular distance restraints such as NOEs or disulfide bonds. When a reliable subunit structure can be calculated from intramolecular restraints, DISCO guarantees that all satisfying oligomer structures will be discovered, yet can run in minutes to hours on only a single desktop-class computer. For further description of DISCO, please refer to our primary publications:
- Jeffrey W. Martin, Anthony K. Yan, Chris Bailey-Kellogg, Pei Zhou, and Bruce R. Donald. A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers. Protein Science, 20(6):970-985, 2011.
- http://dx.doi.org/10.1002/pro.620
- Jeffrey W. Martin, Anthony K. Yan, Chris Bailey-Kellogg, Pei Zhou, and Bruce R. Donald. A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs. Journal of Computational Biology, 18(11): 1507-1523, 2011.
- http://dx.doi.org/10.1089/cmb.2011.0173
DISCO is free software and can be redistributed and/or modified under the terms of the GNU Lesser General Public License as published by the Free Software Foundation, either version 3 of the License, or (optionally) any later version. DISCO is distributed in the hope that they will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public License for more details. Full licensing details, including citation requirements for the various different modules of the software, are found in the README file within the DISCO distribution.
DISCO uses the arrangements package from CGAL generously provided by the computational geometry lab at Tel Aviv University.