Duke University

Mt. Sinai

MIT

New York University

Princeton University

University of Delaware

University of Pennsylvania

University of Rochester

University of Southern California

University of Wisconsin.

These members include all the subcontactor PIs of the DARPA/NSF project in Prototyping Biomolecular Computations.

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Meeting Time: 9-10pm Monday, June 14, 1999, at University Park Hotel, Cambridge, MA.

John Reif chaired the meeting.

David Gifford at MIT chaired the local arrangements.

Duke University

Mt. Sinai

MIT

New York University

Princeton University

University of Delaware

University of Pennsylvania

University of Rochester

University of Southern California

University of Wisconsin.

(1) Brief Update on Reporting for the existing DARPA/NSF grant: Prototyping Biomolecular Computations.

(2) Brief Update on Continued Funding of the existing DARPA/NSF grant: Prototyping Biomolecular Computations. Our FY99 proposal for optional money for large scale experimental prototypes has not been approved (but is not yet officially requested either). DARPA months ago sent NSF the FY99 increment of the existing grant. NSF says that on June 3, 1999 the FY99 increment of the existing grant was approved within NSF, including the amounts NSF contributes. Reif has arranged so that Duke contracts personnel will, on the day the money arrives at Duke from NSF, immediately notify all subcontractors and make available the FY99 increment.

(3) Planning for Future Continued Funding. Our current grant runs though FY2000. Reif is planning a meeting at NSF, Washington DC, (tentatively fall, 1999) to be titled: Biomolecular Computation: Its Potential and Applications. The meeting will be attended by the consortium members, who may be expected to give brief presentations, as well as some additional invited speakers. The meeting will be attended also by program managers from NSF, DARPA, and other agencies. We need to articulate at the meeting the applications of BMC beyond solution of combinatorial search problems, and the potential for scaling up to large scale experimental prototypes.

(4) Plans for Edited Textbook: "Bio-Molecular Computation" to be edited by Reif, with contributed chapters. This edited text (in latex) will cover: the underlying biotechnology that BMC utilizes, a number of distinct paradigms for doing BMC, and experimental techniques the field of BMC, as well as theoretical results.

The textbook outline is available online at

Schedule (Revised by suggestion of N. Seeman)

• One page Chapter Outlines and Abstracts of sections due July 1, 1999.
• Detailed outlines due August 1, 1999.
• Full length drafts of sections due Oct 15, 1999.
• Referee reports of full length drafts due Nov 15, 1999.
• Edited sections due Jan 15, 2000.

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we had a second meeting of the Consortium on Biomolecular Computing and Applications. The Meeeting was Chaired by John Reif,the PI of the grant

Attending members were the PI and the subcontactor PIs from:

Binghamton University

Duke University

Mt. Sinai

New York University

Princeton University

University of Delaware

University of Pennsylvania

University of Rochester

University of Southern California

and University of Wisconsin.

Agendas Items of Meeting:

In the meeting there was a 30 minute presentation by each subcontractor on

detailed progress to date, particularly detailing experimental progress and collaborations to date, FY97 progress and projected FY98 progress with specific details of plans for next year.

We also discussed proposed use of additional optional funds for demonstration of a large scale biomolecular machine solving a given problem.