Publications

D. Sebba, T.H. LaBean & A.A. Lazarides (2008) Two-State Core-Satellite Assemblies with Switchable Plasmonic Behavior (submitted).

S.-H. Park, G. Finkelstein, and T.H. LaBean* (2008) Stepwise Assembly of DNA Tile Lattices using dsDNA Bridges, J. Am. Chem. Soc., 130, 40-41. PDF

J. H. Reif & T. H. LaBean (2007) Beyond silicon: new computing paradigms: Autonomous Programmable Biomolecular Devices Using Self-Assembled DNA Nanostructures. Communications of the Association for Computing Machinery, 50, 46-53. PDF

Thom LaBean* & Hanying Li (2007) Using DNA for Construction of Novel Materials, Nano Today, 26-35. PDF

Thom LaBean (2006) Hydrogels: DNA bulks up. (News & Views) Nature Materials, 5, 767–768.PDF

H. Li, T. H. LaBean* & D. Kenan* (2006) Single-chain antibodies against DNA aptamers as adapter molecules on DNA tile arrays in nanoscale materials organization. Org. Biomol. Chem., 4, 3420 - 3426 (DOI: 10.1039/b606391h).PDF

S-H. Park, M.W. Prior, T.H. LaBean*, and G. Finkelstein* (2006) Optimized fabrication and electrical analysis of silver nanowires templated on DNA molecules. Applied Physics Letters 89, 033901.

S-H. Park, C. Pistol, S.- J. Ahn, J. H. Reif, A. Lebeck, C. Dwyer, and T.H. LaBean (2006) Finite-size, Fully-Addressable DNA Tile Lattices Formed by Hierarchical Assembly Procedures. Angew. Chem, Int. Ed. 45, 735-739 (anie.200503797). PDF /Supporting Information

S-H. Park, M.W. Prior, T.H. LaBean*, and G. Finkelstein* (2006) Optimized fabrication and electrical analysis of silver nanowires templated on DNA molecules. Applied Physics Letters 89, 033901. PDF /Supporting Information

J. Xu, T.H. LaBean, S.L. Craig (2005) DNA Structures and their Applications in Nanotechnology. in Supramolecular Polymers 2 (ed. Alberto Ciferri), ISBN: 0-8247-2331-7, CRC Press - Taylor & Francis Group, Boca Raton.PDF

Milan N. Stojanovic, Darko Stefanovic, Thomas LaBean and Hao Yan (2005) Computing with Nucleic Acids. in Bioelectronics: From Theory to Applications (ed. Itamar Willner), ISBN: 3-527-30690-0, VCH-Verlag.

Kurt V. Gothelf and Thomas H. LaBean (2005) DNA-programmed assembly of nanostructures. Organic & Biomolec. Chem. 3, 4023-4037. PDF

S-H. Park, P. Yin, Y. Liu, J.H. Reif, T.H. LaBean, and Hao Yan (2005) Programmable DNA Self-assemblies for Nanoscale Organization of Ligands and Proteins. Nano Letters 5, 729-733. PDF /Supporting Information

S-H. Park, R. Barish, H. Li, J.H. Reif , G. Finkelstein , H. Yan, and T.H. LaBean (2005) Three-Helix Bundle DNA Tiles Self-assemble into 2D Lattice or 1D Templates for Silver Nanowires. Nano Letters 5, 693-696. PDF /Supporting Information

Thom LaBean & Sung Ha Park (to appear 2005) Self-Assembled DNA Nanotubes. in Biological and Pharmaceutical Nanomaterials (volume 2 in series) Nanotechnologies for the Lifesciences (ed. Challa Kumar), Wiley – VCH.

Sang Jung Ahn, Marian Kaholek, Woo-Kyung Lee, Bruce LaMattina, Thomas H. LaBean, and Stefan Zauscher (2004) Surface-Initiated Polymerization on Nanopatterns Fabricated by Electron-Beam Lithography. Advanced Materials 16, 2141-2145. PDF

Sung Ha Park, Hao Yan, John H. Reif, Thomas H. LaBean and Gleb Finkelstein (2004) Electronic nanostructures templated on self-assembled DNA scaffolds. Nanotechnology 15, S525-S527. PDF

D. Liu, S- H. Park, J. H. Reif, and T.H. LaBean (2004) DNA nanotubes self-assembled from TX tiles as templates for conductive nanowires. Proc. Nat. Acad. Sci., USA 101, 717-722. PDF

H. Li, S- H. Park, J. H. Reif, T. H. LaBean, and Hao Yan, (2004) DNA Templated Self-Assembly of Protein and Nanoparticle Linear Arrays, J. Am. Chem. Soc. 126, 418-419. PDF

K. Trabbic-Carlson, D. E Meyer, L. Liu, R. Piervincenzi, N. Nath, T. LaBean, and A. Chilkoti, (2004)Effect of Protein Fusion on the Transition Temperature of an Environmentally Responsive Elastin-like Polypeptide: A Role for Surface Hydrophobicity? Protein Engineering Design and Selection 17, 57-66. PDF

T.H. LaBean (2004) Bionanotechnology, written by David Goodsell, Quarterly Review of Biology 79, 415.PDF

Yan, H., Feng, L., LaBean, T.H., and Reif, J.H. (2003) Parallel Molecular Computation of Pair-wise XOR Using DNA “String Tile” Self-Assembly, J. Am. Chem. Soc., 125, 14246-14247. PDF

Gehani, A., LaBean, T., and Reif, J. (2004) DNA-based cryptography. in Aspects of Molecular Computing: Essays Dedicated to Tom Head on the Occasion of His 70th Birthday. Series: Lecture Notes in Computer Science, Vol. 2950 (Editors: Jonoska, N.; Paun, G.; Rozenberg, G.), ISBN: 3-540-20781-3, Springer

H. Yan, S.H. Park, G. Finkelstein, J.H. Reif, and T.H. LaBean* (2003) DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires. Science 301, 1882-1884.

Yan, H., LaBean, T.H., Feng, L., and Reif, J.H. (2003)Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices, PNAS 100, 8103-8108. PDF /Supporting Information

LaBean, T.H. (2003) Introduction to self-assembling DNA nanostructures for computation and nanofabrication in Computational Biology and Genome Informatics (eds. Wang, J.T.L., Wu, C.H. & Wang, P.P.), ISBN 981-238-257-7, (World Scientific Publishing, Singapore, 2003). PDF

Liu, D.G., Reif, J.H., and LaBean, T.H. (2002) DNA Nanotubes: Construction and Characterization of Filaments Composed of TX - tile Lattice. in Lecture Notes in Computer Science, Vol. 2568, Editors: M. Hagiya & A. Ohuchi, Proceedings of the 8th International Meeting on DNA-Based Computers (Hokkaido University, Sapporo, Japan, June 2002) ISBN 3-540-00531-5, (Springer, Berlin). PDF

Reif, J.H., LaBean, T.H., Pirrung, M., Rana, V.S., Guo, B., Kingsford, C., and Wickham, G.S. (2001) Experimental Construction of Very Large-Scale DNA Databases with Associative Search Capability. in Lecture Notes in Computer Science, Vol. 2340, Editors: N. Jonoska & N. Seeman, Proceedings of the 7th International Meeting on DNA-Based Computers (University of South Florida, Tampa, June 2001) ISBN 3-540-43775-4, (Springer, Berlin). PDF

Reif, J.H. and LaBean, T.H. (2000) Computationally Inspired Biotechnologies: Improved DNA Synthesis and Associative Search Using Error-Correcting Codes and Vector-Quantization. in Lecture Notes in Computer Science, Vol. 2054, Editors: A. Condon and G. Rozenberg, Proceedings of the 6th International Workshop on DNA-Based Computers (meeting at Leiden, The Netherlands, June 2000) ISBN 3-540-42076-2, (Springer, Berlin).

Reif, J.H., LaBean, T.H., and Seeman, N. (2000) Challenges and Applications for Self-Assembled DNA-Nanostructures. in Lecture Notes in Computer Science, Volume 2054, Editors: A. Condon and G. Rozenberg, Proceedings of the 6th International Workshop on DNA-Based Computers (meeting at Leiden, The Netherlands, June 2000) ISBN 3-540-42076-2, (Springer, Berlin).

Mao, C., LaBean, T.H., Reif, J.H., Seeman, N.C. (2000) Logical computation using algorithmic self-assembly of DNA triple-crossover molecules. Nature.407, 493-496. PDF

LaBean, T.H., Yan, H., Kopatsch, J., Liu, F., Winfree, E., Reif, J.H., and Seeman, N.C. (2000) Construction, Analysis, Ligation, and Self-Assembly of DNA Triple Crossover Complexes. J. Am. Chem. Soc. 122, 1848-1860. PDF

LaBean, T.H., Winfree, E., and Reif, J.H. (1999) Experimental Progress in Computation by Self-Assembly of DNA Tilings. in DIMACS Series in Discrete Mathematics and Theoretical Computer Science, Volume 54, pp 123-140, Editors: E. Winfree and D.K. Gifford, Proceedings of the 5th DIMACS Workshop on DNA Based Computers, MIT, Cambridge. ISBN 0-8218-2053-2 PDF

Gehani, A., LaBean, T.H., and Reif, J.H. (1999) DNA-Based Cryptography. in DIMACS Series in Discrete Mathematics and Theoretical Computer Science, Volume 54, pp 233-249, Editors: E. Winfree and D.K. Gifford, Proceedings of the 5th DIMACS Workshop on DNA Based Computers, MIT, Cambridge. ISBN 0-8218-2053-2.

Lagoudakis, M.G. and LaBean, T.H. (1999) 2D DNA Self-Assembly for Satisfiability. in DIMACS Series in Discrete Mathematics and Theoretical Computer Science, Volume 54, pp 141-154, Editors: E. Winfree and D.K. Gifford, Proceedings of the 5th DIMACS Workshop on DNA Based Computers, MIT, Cambridge. ISBN 0-8218-2053-2 PDF

Schultes, E.A., Hraber, P.T. and LaBean, T.H.(1999) Estimating the Contributions of Selection and Self-Organization in RNA Secondary Structure. J. Molecular Evolution 49, 76-83. PDF

Schultes, E.A., Hraber, P.T. and LaBean, T.H. (1999) A Parameterization of RNA Sequence Space. Complexity 4, 61 - 71.

Word, J.M., Lovell, S.C., LaBean, T.H., Taylor, H.C. Zalis, M.E., Presley, B.K., Richardson, J.S., and Richardson, D.C. (1999) Visualizing and Quantifying Molecular Goodness-of-Fit: Small-Probe Contact Dots with Explicit Hydrogens. J. Molecular Biology 285, 1711-1733. PDF

Schultes, E.A., Hraber, P.T. and LaBean, T.H. (1997) Global Similarities in Nucleotide Base Composition among Disparate Functional Classes of Single-Stranded RNA Imply Evolutionary Convergence. RNA 3, 792-806.  PDF

Gernert, K.M., Surles, M.C., LaBean, T.H., Richardson, J.S., and Richardson, D.C. (1995) The Alacoil: A Very Tight, Antiparallel Coiled-Coil of Helices. Protein Science 4, 2252-2260.

LaBean, T.H., Kauffman, S.A., and Butt, T.R. (1995) Libraries of Random-Sequence Polypeptides Produced with High Yield as Carboxy-Terminal Fusions with Ubiquitin. Molecular Diversity 1, 29-38.

LaBean, T.H. and Kauffman, S.A. (1993) Design of Synthetic Gene Libraries Encoding Random Sequence Proteins with Desired Ensemble Characteristics. Protein Science 2, 1249-1254.

LaBean, T.H., Kauffman, S.A., and Butt, T.R. (1992) Design, Expression, and Characterization of Random Sequence Polypeptides as Fusions with Ubiquitin. FASEB Journal 6, A471. [abstract].

Patents

LaBean, T.H. and Butt, T.R. (U.S. Patents # 5,656,467 and # 5,869,295) Methods and Materials for Producing Gene Libraries. Dates of issue 8/12/97 and 2/9/99, respectively.

Presentations

February 2007. Mid Sweden University (Sundvall, Sweden) Presenter and Opponent for PhD Opposition of Bjšrn Hšgberg

December 2006. Agilent Technologies (Santa Clara, CA) Invited Talk: Self-Assembling DNA Nanostructures for Computation and Nanofabrication.

December 2006. Applied Biosystems Inc. (Foster City, CA) Invited Talk: Self-Assembling DNA Nanostructures for Computation and Nanofabrication.

December 2006. International Electron Devices Meeting (IEEE). San Francisco, CA. Invited Talk in Emerging Technologies Session: Self-Assembling DNA Nanostructures and DNA-Based Nanofabrication

December 2006. Workshop on Current Progress of Education & Research in Computer Science (sponsored by Duke University and the Chinese Association of International Exchange of Personnel) Invited Talk: DNA Nanostructures for Biomolecular Computation.

October 2006.  (Beijing, China) National Center for NanoScience and Technology. Invited talk: Hierarchical strategies in biomolecular self-assembly.

October 2006.  (Beijing, China) International Conference on Bio-Nano-Info Fusion and International Forum on Biochip Technologies.  Invited Talk: Self-Assembling DNA Nanostructures and DNA-based Nanofabrication.

September 2006.  University of Washington, Materials Science Dept., GEMSEC. Invited talk: Hierarchical strategies in molecular self-assembly.

December 2005.  University of California at Santa Barbara, Biomolecular Structure and Engineering Program Seminar, Invited talk.

December 2005.  Veeco, Inc. (Santa Barbara, CA) Invited talk. DNA-based BioNanoTechnology.

November 2005.  NSF Workshop on Nanoscience in Energy Generation, Conversion, and Storage, Washington DC. Invited Talk: BioFabrication Approaches to Nano for Energy.

November 2005.  Auburn University, Department of Chemical Engineering, Invited seminar speaker.

October 2005.  University of Manchester, England.  Special seminar in Life Sciences – Molecules to Cells Division: Self-Assembling DNA Nanostructures and DNA-Based Nanofabrication.

October 2005.  iNANO Autumn School, Aarhus University, Denmark.  Invited Talk: Self-Assembling DNA Nanostructures and DNA-Based Nanofabrication.

August 2005.  Workshop at Hong Kong University of Science and Technology, Hong Kong.  Two Invited talks: DNA Computing.  Recent Progress in DNA Nanotechnology.

May 2005. International Symposium on Biointerface Science, New Bern, NC. Invited talk: Self-Assembling DNA Nanostructures and DNA-based Nanofabrication.

April 2005. Foundations of Nanoscience, Snowbird, Utah. Submitted Talk: Self-assembled 1D DNA Nanostructures as Templates for Silver Nanowires

November 2004. Southeast Regional American Chemical Society Meeting, RTP, NC. Submitted talk: Overview of New Structures for DNA-based Nanofabrication and Computation   PDF /Abstract /Supporting Information

October 2004. Foresight Institute, 1st Conference on Advanced Nanotechnology, Washington, D.C. Invited poster: New Structures for DNA-Based Nanofabrication and Computation

September 2004. Chips-to-Hits/Protein Arrays Meeting, Boston. Invited Talk: Self-Assembling DNA Nanostructures as Scaffolds for Protein Arrays

June 2004. 10th International Meeting on DNA Based Computers, Milano, Italy. Invited Tutorial: Self-assembly.

June 2004. iNANO Institute Seminar Series, Aarhus University, Denmark. Invited Talk title: Self-Assembling DNA Structures for Nanofabrication and Computation

April 2004. Foundations of Nanoscience, Snowbird, Utah. Invited Talk: Hierarchical and Serial DNA Self-Assemblies.

September 2003. JCIS-CINC Talk title: New DNA Nanostructures for Computation and Nanofabrication.

June 2003. International Symposium on Sensor Science, Paris, France. Submitted Talk: Self-Assembling DNA Nanostructures for Sensors.

June 2003. 9th International Meeting on DNA Based Computers, Madison, WI. Talk title: 4x4 DNA tile and lattices: Characterization, self-assembly and metallization of a novel DNA nanostructure motif.

June 2002. 8th International Meeting on DNA Based Computers, Hokkaido University, Sapporo, Japan. Talk title: DNA Nanotubes: Construction and Characterization of Filaments Composed of TX -tile Lattice.

March 2002. 4th Conference on Computational Biology and Genome Informatics. Research Triangle Park, North Carolina. Talk title: Self-assembling DNA nanostructures for computation and nanofabrication.

March 2001. Banquet speaker for Atlantic Symposium on Computational Biology and Genome Information Systems and Technology. Duke University. Talk title: Navigating sequence spaces by random evolution and rational engineering.

December 2000. Mount Sinai Medical Center, New York. Presentation to mission from the French National Office of Science and Technology. Talk title: Computation and nano-fabrication by DNA self-assembly.

November 1999. NSF/DARPA Workshop on DNA Computing, Washington D.C. Talk title: DNA lattice self- assembly and formation of gold nano-wires.

June 1999. 5th Annual DIMACS Workshop on DNA Computers, MIT, Cambridge, MA. Talk title: Experimental progress in computation by self-assembled DNA tilings.

Spring 1999. Invited Seminar. Department of Microbiology, North Carolina State University, Raleigh, NC. Talk title: DNA-based computers -- history, theory, and experiments.

November 1995. Workshop for Nonlinear Dynamics in Molecular Evolution and Engineering, UCLA. Talk title: How common is folding in random sequence proteins?

July 1994. (with S.A. Kauffman and T.R. Butt) 8th Symposium of the Protein Society, San Diego. Poster title: Evidence of folded structure in libraries of random sequence polypeptides.

Winter 1994. (with J.S. Richardson) Workshop and Meeting of the Diversity Biotechnology Consortium, Los Alamos National Laboratory. Talk title: Redesign of core packing in MS2 bacteriophage coat protein.

February 1992. (with S.A. Kauffman and T.R. Butt) ASBMB/Biophysical Society Meeting, 2/92, Houston) Poster title: Design, expression, and characterization of random sequence polypeptides as fusions with ubiquitin.

Current Funding

NSF NUE Grant EEC-0634230: NUE: Integrating Nanoscale Systems and Design into Undergrad Engineering and Science Curricula. (PI: H.A. Gimm  CoPIs: T.H. LaBean, C. Roy, D. Needham, Kam Leong). 5/1/07 – 4/30/09 $199,980

NSF NER Grant BES-0609288: NER: Electronic Nanostructures Based on Self-Assembled DNA Scaffolds: toward Biochemical Sensing;  (PI: Gleb Finkelstein  CoPI: Thomas H. LaBean). 6/15/06 – 5/30/07 $130,000

NSF IRES Grant OISE-0624012: IRES: U.S.-Danish Cooperative Research and Education in DNA Nanotechnology (PI: T.H. LaBean). 10/1/06 – 9/30/09 $149,999.

NSF SGER Grant CCF- 0650083: SGER: Strategies for Increasing Stability of Self-Assembling DNA Nanostructures (PI: T.H. LaBean). 10/1/06 – 9/30/08 $139,823.

NSF Grant BES-05-08284: NER: Addressable DNA NanoArrays for Force Spectroscopy of Molecules Relevant to Protein Aggregation (PI T.H. LaBean, coPI Boris Akhremitchev), June 15, 2005-June 14, 2006, $100,000.

NSF EMT Grant CCF-04-32038: Nano: Error-Resilient DNA Tiling Assemblies (PI John Reif, coPI Thomas H. LaBean), Sept. 1, 2004-Aug. 30, 2007, $274,000.

NSF EMT Grant CCF-04-53685: NANO: Combinatorial Self-assembly of Nanocircuits on Addressable DNA Nanoscaffolds. PI Hao Yan coPIs: Thomas LaBean, Chris L. Dwyer, Gleb Finkelstein, John H. Reif, Sept. 1, 2004-Aug. 30, 2007, $295,000.

Taiko Denki Inc. Industrial Grant: Applications of DNA Self-Assembly Nanofabrication Technology to Molecular Scale Electrical Contacts. Taiko Denki Inc., 3-7-3 Yaguchi, Ohta-ku, Tokyo, Japan 146-8668, PIs: Thomas H. LaBean and John Reif, Jan. 1, 2004-Dec. 30, 2004, $55,000.(renewable in FY2005 for $55,000).

NSF QuBIC Grant Number NSF-EIA-02-18376 9/1/02 – 8/31/05 $349,989. Project Title QuBIC: Novel DNA Nanostructures for Targeted Molecular Scale to Micron Scale Interconnects PI: Thomas H. LaBean Co-PI: John Reif

NSF Information Technology Research NSF-CCR-03-26157. 9/1/03 – 8/31/06 $1,200,000. Project Title ITR: Nanoarchitecture: Balancing Regularity, Complexity, and Defect Tolerance using DNA for Nanoelectronic Integration. PI: Alvin Lebeck CoPIs: Thomas H. LaBean, Daniel Sorin, Paul Franzon, John Reif, Hao Yan, Dorothy Erie, and Sean Washburn