Alberto Bartesaghi
Associate Professor of Computer Science, Associate Professor of Biochemistry, Associate Professor of Electrical and Computer Engineering, Faculty Network Member of the Duke Institute for Brain Sciences
- Faculty Area:
- Algorithms
- Email:
- alberto at cs.duke.edu
- Office:
- D338 LSRC
- Phone:
- (919) 660-6579
- Web page:
- http://cryoem.cs.duke.edu
Education
Ph.D., Electrical and Computer Engineering, University of Minnesota, 2005
M.Sc., Electrical Engineering, Universidad de la Republica, Uruguay, 2001
B.Sc., Electrical Engineering, Universidad de la Republica, Uruguay, 1999
Honors & Awards
- 13th Annual Staff Scientist and Staff Clinician Retreat Best Poster Award, Center for Cancer Research, 2017
- National Cancer Institute Director’s 10-Year Length of Service Award, National Institutes of Health, 2016
- Norman P. Salzman Memorial Award in Virology, Foundation for the National Institutes of Health, 2008
- Ericsson Graduate Fellowship Award from the Comision Academica de Posgrado, Universidad de la Republica, 2000
Research
Computational and Structural Biology, High-Resolution Electron Microscopy, Single-Particle Analysis, Cryo-Electron Tomography, Image Analysis, Computer Vision, Machine Learning, Biomedical Imaging, Applied Mathematics.
Selected Publications
- Atomic Resolution Cryo-EM Structure of Beta-Galactosidase, with Aguerrebere C, Falconieri V, Banerjee S, Earl LA, Zhu X, Grigorieff N, Milne JLS, Sapiro G, Wu X, and Subramaniam S. Structure. 26(6), 2018.
- Cryo-EM structures reveal mechanism and inhibition of DNA targeting by a CRISPR-Cas surveillance complex, with Guo TW, Yang H, Falconieri V, Rao P, Merk A, Eng ET, Raczkowski AM, Fox T, Earl LA, Patel DJ, and Subramaniam S. Cell. 171(2): 414-426, 2017.
- Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery, with Merk A, Banerjee S, Falconieri V, Rao P, Davis M, Pragani R, Boxer M, Earl LA, Milne JLS, and Subramaniam S. Cell. 165(7): 1698-1707, 2016.
- 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition, with Banerjee S, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JLS, Huryn D, Arkin M, and Subramaniam S. Science. 351(6275): 871-875, 2016.
- 2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor, with Merk A, Banerjee S, Matthies D, Wu X, Milne JLS, and Subramaniam S. Science. 348(6239): 1147-1151, 2015.
Extended lists of publications
Google Scholar and PubMed