Bruce Donald

Bruce Randall Donald

James B. Duke Professor
      of Computer Science and Chemistry
Professor of Biochemistry
Professor of ECE

Duke University


Contact, Email, FAQ

Algorithms in Structural Molecular Biology,  MIT Press (2011)
Textbook (MIT Press).

Welcome to Bruce Donald's homepage. I am a Professor of Computer Science and Chemistry at Duke University, and Professor of Biochemistry in the Duke University Medical Center. I am also Professor of Electrical and Computer Engineering in the Duke Pratt School of Engineering.

My laboratory is part of the

We are grateful to our funders for their support.

You can browse my books and papers, learn about research in my laboratory, or take my (not entirely?)
Random Walk:
  1976-1980 Yale, B.A.
  1980-1984 Harvard, GSD
  1982-1987 MIT, Ph.D. in Computer Science
  1987-1998 Cornell Computer Science Department, Professor
  1994-1996 Stanford University, Sabbatical
  1995-1997 Interval Research Corporation
  1997-2006 Dartmouth, Professor
  2006-now  Duke, Professor.


Feel free to check out classes I teach, and my lab in the news.

Here are tips on using LaTeX for NIH grant applications, and seminars of interest for lab members.

Our lab has a YouTube channel.

I have a bit of fun stuff: you can check out my band, more music (MP3s), MEMS movies, robot movies, and other hacks.


    If you are interested in joining my laboratory, please read my brief FAQ.

    Contact:
    Bruce R. Donald
    Professor of Computer Science
    Professor of Biochemistry, Duke University Medical Center
    P.O. Box 90129
    Department of Computer Science
    D101 Levine Science Research Center (LSRC)
    Research Drive
    Duke University
    Durham, NC 27708-0129 USA


    Please do not publish my e-mail address on any website or mailing list or book (yes, people have actually published books that are lists of scientists' email addresses). It will cause me to receive spam, since the address can be harvested by advertisers.
    It's my initials: `b' followed by `r' followed
by `d' `at' `cs' period `duke' period 'edu'.
    Phone: 919-660-6583

    Office: D212 Levine Science Research Center (LSRC)
    Please note that our lab has moved to great new space:
    Dry-Lab: D240 LSRC, 660-4017
    Wet-Lab: 3245, 3246, & 3248 French Family Science Center, 660-4018

    Google map; Duke Maps: LSRC, French Center


    Et cette proposition est généralement vraie en toutes progressions et en tous nombres premiers; de quoi je vous envoierois la démonstration, si je n'appréhendois d'être trop long.


Some of our papers (See all)

Drug Design


Combatting Leukemia:
RUNX1 and CBFβ Interaction Interupted.
Chemistry & Biology (2007).


Protein Structures Gallery

Structure of a membrane-associated MPER trimer from HIV-1 gp41


PDB id: 2m7w.


Solution structure of FF Domain 2 of human transcription elongation factor CA150.
PDB ID: 2KIQ (J. Biomol. NMR 2009)

Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis.
PDB ID: 1QZF (J. Biol. Chem.)

Complete ensemble of NMR structures of the unphosphorylated human cardiac phospholamban pentamer. PDB ID: 2HYN (Proteins, 2006)

Nanoscience and Microelectromechanical Systems


Independent Control of Stress-engineered MEMS Microrobots
.
Robotics: Systems and Science (2012)


Planar Microassembly by Parallel Actuation
of MEMS Microrobots.
Journal of Microelectromechanical Systems (2008).

Neuroscience, Microtechnology, and Nanotechnology


Auditory synapses to song premotor neurons
eLife (2014)



Intracellular Neural Recording with
Pure Carbon Nanotube Probes


PLoS (2013).



Recent Papers (See all)

An enhanced anti-HIV broadly neutralizing antibody
Journal of Virology (2014)


Structure of an HIV Neutralizing Antibody Target: A Lipid Bound gp41 Envelope Membrane Proximal Region Trimer.
PNAS (2014)


Protein Design


Predicting Resistance Mutations using Protein Design Algorithms.
PNAS (2010).


Computational Structure-Based Redesign of Enzyme Activity.
PNAS (2009).


Design of Epitope-Specific Probes for Sera Analysis and Antibody Isolation


Retrovirology (2012).

OSPREY: Protein Design with Ensembles, Flexibility, and Provable Algorithms


Methods in Enzymology (2013)

Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity


PLoS Computational Biology (April, 2012).

Protein Design using Continuous Rotamers


PLoS Computational Biology (Jan., 2012).

The Role of Local Backrub Motions in Evolved and Designed Mutations

PLoS Computational Biology (August, 2012).

PROTEINS
Cover Article

Protein loop closure using orientational restraints from NMR data. Proteins (2011)

DEEPer: A provable protein design algorithm with continuous sidechain and backbone flexibility


Proteins (July, 2012).



Carbon nanotube-based probes for scanning microscopy and neural recording


Journal of Applied Physics (2012).


Microassembly by Microrobots


International Journal of Robotics Research (2013)